Antibacterial Studies of Dihydropyrimidinones and Pyrimidinethiones
ثبت نشده
چکیده
Heterocyclic compounds containing nitrogen are promising structure moiety for drug design. Dihydropyrimidines are one of the important heterocyclic compounds, which are of interest due to its efficiency towards various pharmacological uses. These are large group of structurally diverse compounds which are known to possess some characteristic properties like manifestations of novel structures, thermal stability, relevant biological properties, high synthesis flexibility and medicinal utility [1-12]. Further, some of dihydropyrimidines are reported to overcome multidrug resistance efficiently [13].
منابع مشابه
Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin.
3,4-Dihydropyrimidinones of curcumin were synthesized in excellent yield by multi-component one-pot condensation of curcumin, substituted aromatic aldehydes and urea/thiourea under solvent free conditions using SnCl(2)·2H(2)O catalyst. All the synthesized compounds have been characterized by IR, (1)H NMR, (13)C NMR, Mass spectra as well as elemental analyses. The synthesized compounds 4a-n were...
متن کاملBiginelli Synthesis and Theoritical Study of Dihydropyrimidinones
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.
متن کاملEfficient Oxidative Dehydrogenation of Dihydropyrimidinones and Thiocyanation of Aromatic Compounds Using 1,1,2,2-Tetrahydroperoxy-1,2-diphenylethane as the Oxidant
A new, efficient and mild approach for the oxidative dehydrogenation of dihydropyrimidinones and thiocyanation of aromatic compounds using 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane (THPDPE) as a terminal oxidant was developed. Initially, various substrates bearing different electron-donating and electron-releasing functionalities were synthesized and next under the optimized reaction conditio...
متن کاملEfficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde
A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and regioselectivity to give highly diverse dihydropyrimidinones in reasonable yields under mild reaction conditions. Moreover, the first catalyti...
متن کاملChemo-/regioselective synthesis of 6-unsubstituted dihydropyrimidinones, 1,3-thiazines and chromones via novel variants of Biginelli reaction.
A novel and facile cascade Biginelli-like assembly employing enaminone, aldehyde and urea/thiourea has been developed, which provides a highly chemo- and regioselective synthesis of new dihydropyrimidinones, 1,3-thiazines and chromones by altering particular functional groups in the reactants.
متن کامل